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NADPH is used by glutathione reductase to regenerate GSH from GSSG, thus they work hand in hand

When the gcs-1 gene was knocked down immediately after worm hatching, no difference was observed in median lifespan, though a higher incidence of vulval rupture and a significantly lower resistance against paraquat exposure was observed [58]

GSH activity is facilitated by activation of the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 that regulates expression of genes controlling antioxidant, inflammatory and immune system responses

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